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4584-46-7 Usage

Appearance

2-Dimethylaminoethyl chloride hydrochloride is white to Off-White Solid

Applications

2-Chloro-N,N-dimethylethylamine is a widely used as an intermediate and starting reagent for organic synthesis.

Dangerous Goods Info

Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Uses

Different sources of media describe the Uses of 4584-46-7 differently. You can refer to the following data:
1. 2-Chloro-N,N-dimethylethylamine hydrochloride (DMC) is used as intermediate for the synthesis of pharmaceuticals (e.g. bephenium hydroxnaphthoate, diltiazem, mepyramine and phenyltoloxamine). Product Data Sheet
2. 2-Chloro-N,N-dimethylethylamine is a widely used as a intermediate and starting reagent for organic synthesis.
3. 2-Chloro-N,N-dimethylethylamine is a widely used as a intermediate and starting reagent for organic synthesis. Also acts as Intermediate for the syntheses of bephenium hydroxynaphthoate, diltiazem, mepyramine and phenyltoloxamine.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx

Check Digit Verification of cas no

The CAS Registry Mumber 4584-46-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,8 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4584-46:
(6*4)+(5*5)+(4*8)+(3*4)+(2*4)+(1*6)=107
107 % 10 = 7
So 4584-46-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H10ClN.ClH/c1-6(2)4-3-5;/h3-4H2,1-2H3;1H

4584-46-7 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (A15134)  2-Dimethylaminoethyl chloride hydrochloride, 98+%   

  • 4584-46-7

  • 100g

  • 120.0CNY

  • Detail
  • Alfa Aesar

  • (A15134)  2-Dimethylaminoethyl chloride hydrochloride, 98+%   

  • 4584-46-7

  • 500g

  • 508.0CNY

  • Detail
  • Aldrich

  • (D141208)  2-Chloro-N,N-dimethylethylaminehydrochloride  99%

  • 4584-46-7

  • D141208-500G

  • 651.69CNY

  • Detail

4584-46-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Dimethylaminoethyl chloride hydrochloride

1.2 Other means of identification

Product number -
Other names 2-Chloro-N,N-dimethylethylamine Hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4584-46-7 SDS

4584-46-7Synthetic route

2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 0 - 20℃;100%
With thionyl chloride at 0℃; for 20h;98%
With thionyl chloride for 12h; Ambient temperature;92%
dimethyl amine
124-40-3

dimethyl amine

2-chloro-ethanol
107-07-3

2-chloro-ethanol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

Conditions
ConditionsYield
Stage #1: dimethyl amine; 2-chloro-ethanol for 4h; Reflux;
Stage #2: With thionyl chloride In tetrachloromethane at 20℃; for 4h; Cooling with ice;
60.8%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

2-nitro-10H-indolo[3,2-b]quinoline
182123-57-5

2-nitro-10H-indolo[3,2-b]quinoline

2-nitro-10-dimethylaminoethylindolo[3,2-b]quinoline

2-nitro-10-dimethylaminoethylindolo[3,2-b]quinoline

Conditions
ConditionsYield
With sodium hydroxide; dimethyl sulfoxide at 20℃; for 4h; Substitution;100%
3-(cyano-dimethyl-methyl)-5-hydroxy-benzoic acid methyl ester
873450-59-0

3-(cyano-dimethyl-methyl)-5-hydroxy-benzoic acid methyl ester

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

3-(cyano-dimethyl-methyl)-5-(2-dimethylamino-ethoxy)-benzoic acid methyl ester
878744-07-1

3-(cyano-dimethyl-methyl)-5-(2-dimethylamino-ethoxy)-benzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone for 5h; Heating / reflux;100%
3-nitro-o-cresol
5460-31-1

3-nitro-o-cresol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

dimethyl{2-[(2-methyl-3-nitrophenyl)oxy]ethyl}amine
1089278-90-9

dimethyl{2-[(2-methyl-3-nitrophenyl)oxy]ethyl}amine

Conditions
ConditionsYield
With potassium carbonate In water; butan-1-ol at 80℃; for 13h;100%
(E)-3-Tetrahydropyranyloxy-7α-methyl-21-hydroxy-19-norpregna-1,3,5(10),17(20)-tetraene
229635-02-3

(E)-3-Tetrahydropyranyloxy-7α-methyl-21-hydroxy-19-norpregna-1,3,5(10),17(20)-tetraene

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

C30H45NO3

C30H45NO3

Conditions
ConditionsYield
Stage #1: (2-chloroethyl)dimethylamine hydrochloride With sodium hydride In N,N-dimethyl-formamide at 0℃;
Stage #2: (E)-3-Tetrahydropyranyloxy-7α-methyl-21-hydroxy-19-norpregna-1,3,5(10),17(20)-tetraene With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 70℃; for 2.5h;
100%
(Z)-4-[2-(3-methoxyphenyl)-1-phenylbut-1-en-1-yl]phenol

(Z)-4-[2-(3-methoxyphenyl)-1-phenylbut-1-en-1-yl]phenol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(Z)-2-{4-[2-(3-methoxyphenyl)-1-phenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine

(Z)-2-{4-[2-(3-methoxyphenyl)-1-phenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine

Conditions
ConditionsYield
Stage #1: (Z)-4-[2-(3-methoxyphenyl)-1-phenylbut-1-en-1-yl]phenol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: (2-chloroethyl)dimethylamine hydrochloride In N,N-dimethyl-formamide at 80℃; for 2h;
100%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

trans-(2R,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
132830-17-2

trans-(2R,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2R,3S)-5-<2-(dimethylamino)ethyl>-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
91926-66-8

(2R,3S)-5-<2-(dimethylamino)ethyl>-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone Heating;98.7%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-3-Hydroxy-8-isopropyl-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-3-Hydroxy-8-isopropyl-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-3-hydroxy-8-isopropyl-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-3-hydroxy-8-isopropyl-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;98%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-3-Hydroxy-8-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-3-Hydroxy-8-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-3-hydroxy-8-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-3-hydroxy-8-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;98%
With potassium carbonate In acetone Heating;89%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-8-Ethoxy-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Ethoxy-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-5-(2-Dimethylamino-ethyl)-8-ethoxy-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-5-(2-Dimethylamino-ethyl)-8-ethoxy-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;98%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-8-Cyclohexyl-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Cyclohexyl-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Cyclohexyl-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Cyclohexyl-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;98%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-8-Cyclopentyloxy-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Cyclopentyloxy-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Cyclopentyloxy-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Cyclopentyloxy-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;98%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-3-Hydroxy-2-(4-methoxy-phenyl)-8-phenoxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-3-Hydroxy-2-(4-methoxy-phenyl)-8-phenoxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-8-phenoxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-8-phenoxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;98%
Benzophenone oxime
574-66-3

Benzophenone oxime

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

O-(2-dimethylaminoethyl)benzophenone oxime
3362-42-3

O-(2-dimethylaminoethyl)benzophenone oxime

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Alkylation;98%
With sodium hydroxide; 18-crown-6 ether In dimethyl sulfoxide at 40℃; for 48h;59%
With potassium hydroxide In dimethyl sulfoxide26%
With sodium methylate In methanol Heating;
(i) NaH, EtOH, (ii) /BRN= 3591234/; Multistep reaction;
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

4-Hydroxybenzophenone
1137-42-4

4-Hydroxybenzophenone

(4-(2-(dimethylamino)ethoxy)phenyl)(phenyl)methanone
51777-15-2

(4-(2-(dimethylamino)ethoxy)phenyl)(phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Heating;98%
With sodium ethanolate In ethanol for 24h; Heating;90%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 5h;
With potassium carbonate In acetone at 56 - 57℃; for 12h;
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 30 - 60℃; for 7.16667h;8.55 g
3,7-dibromo-5-hydroxyimino-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene

3,7-dibromo-5-hydroxyimino-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

3,7-dibromo-5-(dimethylaminoethyloxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene

3,7-dibromo-5-(dimethylaminoethyloxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene

Conditions
ConditionsYield
With potassium carbonate In acetone for 15h; Heating;98%
C19H14N2O

C19H14N2O

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

N,N-dimethyl-2-[(4-{4-(6-methyl-pyridin-2-yl-ethynyl)-pyridin-2-yl}phenyl)oxy]ethanamine

N,N-dimethyl-2-[(4-{4-(6-methyl-pyridin-2-yl-ethynyl)-pyridin-2-yl}phenyl)oxy]ethanamine

Conditions
ConditionsYield
With potassium carbonate In acetone Heating / reflux;98%
With potassium carbonate In acetone Heating / reflux;98%
4-benzyloxy-2-dodecylquinolin-6-ol
1270008-55-3

4-benzyloxy-2-dodecylquinolin-6-ol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

4-benzyloxy-6-[2-(dimethylamino)ethoxy]-2-dodecylquinoline
1270008-56-4

4-benzyloxy-6-[2-(dimethylamino)ethoxy]-2-dodecylquinoline

Conditions
ConditionsYield
Stage #1: 4-benzyloxy-2-dodecylquinolin-6-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: (2-chloroethyl)dimethylamine hydrochloride In N,N-dimethyl-formamide; mineral oil at 100℃; for 2h; Inert atmosphere;
98%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

1-phenyl-1-(pyridin-2-yl)ethanol
19490-92-7

1-phenyl-1-(pyridin-2-yl)ethanol

doxylamine
469-21-6

doxylamine

Conditions
ConditionsYield
Stage #1: 1-phenyl-1-(pyridin-2-yl)ethanol With sodium amide In 5,5-dimethyl-1,3-cyclohexadiene Inert atmosphere;
Stage #2: (2-chloroethyl)dimethylamine hydrochloride In 5,5-dimethyl-1,3-cyclohexadiene for 1h; Time; Reflux;
98%
4-(4-hydroxyphenyl)-3,4-diphenyl-but-3-en-1-ol
89778-37-0

4-(4-hydroxyphenyl)-3,4-diphenyl-but-3-en-1-ol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(Z)-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-buten-4-ol
97151-03-6

(Z)-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-buten-4-ol

Conditions
ConditionsYield
With potassium carbonate In acetone at 25 - 50℃; for 5h; Solvent; Reagent/catalyst; Temperature;98%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(+/-)-trans-(2R,3S)-8-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one
96125-50-7

(+/-)-trans-(2R,3S)-8-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

(2R,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
130979-60-1

(2R,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 17h; Heating;97.7%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-3-Hydroxy-8-methyl-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-3-Hydroxy-8-methyl-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-5-(2-Dimethylamino-ethyl)-3-hydroxy-8-methyl-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-5-(2-Dimethylamino-ethyl)-3-hydroxy-8-methyl-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone Heating;97.5%
trans-6-methoxy-1,1-dimethyl-2,3-diphenyl-2,3-dihydro-1H-inden-4-ol

trans-6-methoxy-1,1-dimethyl-2,3-diphenyl-2,3-dihydro-1H-inden-4-ol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

C28H33NO2

C28H33NO2

Conditions
ConditionsYield
In isopropyl alcohol at 53 - 55℃; for 3h;97.3%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

cis-(+)-2-(4'-methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepine-4(5H)-one
42399-51-9

cis-(+)-2-(4'-methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepine-4(5H)-one

butanone
78-93-3

butanone

A

cis-(+)-3-hydroxy-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4-methoxyphenyl-1,5-benzothiazepine-4(5H)-one

cis-(+)-3-hydroxy-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4-methoxyphenyl-1,5-benzothiazepine-4(5H)-one

B

diltiazem
42399-41-7

diltiazem

Conditions
ConditionsYield
With acetic anhydride; potassium carbonate In waterA 97.2%
B n/a
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-8-Ethyl-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-8-Ethyl-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-8-ethyl-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2R,3R)-5-(2-Dimethylamino-ethyl)-8-ethyl-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;97%
With potassium carbonate In acetone Heating;93.1%
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(2S,3S)-3-Hydroxy-2-(4-methoxy-phenyl)-8-m-tolyloxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(2S,3S)-3-Hydroxy-2-(4-methoxy-phenyl)-8-m-tolyloxy-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 16h; Heating;97%
(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With potassium carbonate In ethanol; toluene at 80 - 85℃; for 3h; Inert atmosphere;97%
With sodium ethanolate In ethanol for 24h; Heating;62%
With sodium hydride 1.) DMF, 2.) 60 deg C, 30 min; Yield given. Multistep reaction;

4584-46-7Relevant articles and documents

A high-efficacy and regenerable antimicrobial resin containing quaternarized N-halamine groups

Jie, Zhiqiang,Yan, Xiufang,Zhao, Lianhong,Worley,Liang, Jie

, p. 1580 - 1587 (2013)

A novel macroporous cross-linked antimicrobial resin containing quaternarized N-halamine groups, poly(1-chloro-5,5-dimethylhydantoinyl-3-ethyl- p-ethenylphenylmethyl dimethylammonium chloride) (Cl-PSQH), has been synthesized by a facile three-step reaction. The as-prepared resins were characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. Antimicrobial tests showed that Cl-PSQH was capable of about a 7-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min of contact. Also, its regenerability and preliminary storage stability were investigated.

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

-

Paragraph 00230; 00410; 00658, (2020/07/05)

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Synthetic process of 2-dimethylaminoethyl chloride hydrochloride

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Paragraph 0015; 0020-0022, (2018/04/01)

The invention discloses a synthetic process of 2-dimethylaminoethyl chloride hydrochloride. The synthetic process comprises the following steps: taking dimethylethanolamine as a raw material, controlling the temperature to 10 to 15 DEG C and carrying out direct chlorination reaction on the dimethylethanolamine and thionyl chloride; adding absolute ethyl alcohol for carrying out a reflux reaction for one hour; filtering and drying to obtain a finished product. The synthetic process of the 2-dimethylaminoethyl chloride hydrochloride, provided by the invention, has the advantages of simple steps, high yield, good quality, low cost, mild reaction and convenience in operation; the purity of a product is high, i.e., the percentage of inorganic salt is less than 0.5 percent; three wastes are reduced, as hydrogen chloride gas and sulfur dioxide gas in the reaction are absorbed; a mother solution which is subjected to suction filtration does not need to be treated and is treated as waste liquid, so that environment protection is facilitated.

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