diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate

Base Information

• Chemical Name: diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate
• CAS No.: 1262340-37-3
• Molecular Formula: C₂₇H₂₇Cl₂NO₆S
• Molecular Weight: 564.486
• Mol file: 1262340-37-3.mol

Synonyms:diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate

Chemical Property of diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate

There total 2 articles about diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-2-(Bis-ethylsulfanyl-methylene)-5-(4-chloro-phenyl)-3-oxo-pent-4-enoic acid (4-chloro-phenyl)-amide (850997-68-1) + diethyl malonate (105-53-3) → diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate (1262340-37-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 5h; chemoselective reaction;

DOI:10.1016/j.tetlet.2010.10.129

Reference yield:

C27H27Cl2NO6S → diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate (1262340-37-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 1h; chemoselective reaction;

DOI:10.1016/j.tetlet.2010.10.129

Reference yield: 83.0%

diethyl 2-((2E,4E)-5-(4-chlorophenyl)-2-(4-chlorophenylcarbamoyl)-1-(ethylthio)-3-hydroxypenta-2,4-dienylidene)malonate (1262340-37-3) → ethyl 1-(4-chlorophenyl)-5-((Z)-3-(4-chlorophenyl)-1-hydroxyallylidene)-4-(ethylthio)-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carboxylate (1262340-49-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 20 ℃; Reflux;

DOI:10.1016/j.tetlet.2010.10.129

upstream raw materials:

(E)-2-(Bis-ethylsulfanyl-methylene)-5-(4-chloro-phenyl)-3-oxo-pent-4-enoic acid (4-chloro-phenyl)-amide

diethyl malonate

Downstream raw materials:

ethyl 1-(4-chlorophenyl)-5-((Z)-3-(4-chlorophenyl)-1-hydroxyallylidene)-4-(ethylthio)-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carboxylate