6-(PYRROLIDINE-1-CARBONYL)-CYCLOHEX-3-ENECARBOXYLIC ACID

Base Information

• Chemical Name: 6-(PYRROLIDINE-1-CARBONYL)-CYCLOHEX-3-ENECARBOXYLIC ACID
• CAS No.: 355830-81-8
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Hs Code.: 2933990090
• Mol file: 355830-81-8.mol

Synonyms:6-(PYRROLIDINE-1-CARBONYL)-CYCLOHEX-3-ENECARBOXYLIC ACID

Chemical Property of 6-(PYRROLIDINE-1-CARBONYL)-CYCLOHEX-3-ENECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 6.74E-09mmHg at 25°C
• Boiling Point: 438°Cat760mmHg
• Flash Point: 218.7°C
• PSA: 57.61000
• Density: g/cm³
• LogP: 1.21370

Purity/Quality:

97% ^*data from raw suppliers

6-(pyrrolidine-1-carbonyl)cyclohex-3-ene-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(PYRROLIDINE-1-CARBONYL)-CYCLOHEX-3-ENECARBOXYLIC ACID

There total 2 articles about 6-(PYRROLIDINE-1-CARBONYL)-CYCLOHEX-3-ENECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pyrrolidine (123-75-1) + cis-1,2,3,6-tetrahydrophthalic anhydride (935-79-5) → (1SR,6RS)-6-(pyrrolidine-1-carbonyl)cyclohex-3-enecarboxylic acid (355830-81-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol801007m

Reference yield:

C17H25NO4 + isopropyl alcohol (67-63-0,8013-70-5) → (1SR,6RS)-6-(pyrrolidine-1-carbonyl)cyclohex-3-enecarboxylic acid (355830-81-8) + (+)-isopropyl (1R,6S)-6-(pyrrolidine-1-carbonyl)cyclohex-3-enecarboxylate + (-)-isopropyl (1S,6R)-6-(pyrrolidine-1-carbonyl)cyclohex-3-enecarboxylate

Guidance literature:

C₁₇H₂₅NO₄; isopropyl alcohol; With Trimethylacetic acid; (S)-(+)-1-tert-butyldiphenylsilyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; In tetrachloromethane; at 0 ℃; for 25h; Inert atmosphere;

With hydrogenchloride; water; In tetrachloromethane; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol801007m

upstream raw materials:

pyrrolidine

cis-1,2,3,6-tetrahydrophthalic anhydride

isopropyl alcohol