(2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester
• CAS No.: 340961-33-3
• Molecular Formula: C₂₅H₃₁N₇O₅
• Molecular Weight: 509.565
• Mol file: 340961-33-3.mol

Synonyms:(2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property of (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester

There total 2 articles about (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-benzoyladenine (4005-49-6) + 1-(N-[2-(tert-butoxycarbonylamino)ethyl])-(4R)-O-mesyl-2-(S)-proline methyl ester (340961-32-2) → (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester (340961-33-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ol015546k

Reference yield:

1-(N-[2-(tert-butoxycarbonylamino)ethyl])-4-(R)-hydroxy-2-(S)-proline methyl ester (253307-68-5) → (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester (340961-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / pyridine

2: 65 percent / K₂CO₃ / dimethylformamide

With potassium carbonate; In pyridine; N,N-dimethyl-formamide;

DOI:10.1021/ol015546k

Reference yield: 95.0%

(2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid methyl ester (340961-33-3) → (2S,4S)-4-(6-Benzoylamino-purin-9-yl)-1-(2-tert-butoxycarbonylamino-ethyl)-pyrrolidine-2-carboxylic acid

Guidance literature:

With sodium hydroxide; In methanol; water;

DOI:10.1021/ol015546k

upstream raw materials:

N-benzoyladenine

1-(N-[2-(tert-butoxycarbonylamino)ethyl])-(4R)-O-mesyl-2-(S)-proline methyl ester

1-(N-[2-(tert-butoxycarbonylamino)ethyl])-4-(R)-hydroxy-2-(S)-proline methyl ester