5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole

Base Information

• Chemical Name: 5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole
• CAS No.: 1272644-68-4
• Molecular Formula: C₂₆H₃₅NO₇Si
• Molecular Weight: 501.652
• Mol file: 1272644-68-4.mol

Synonyms:5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole

Chemical Property of 5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole

There total 2 articles about 5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(tert-Butyldimethylsilyloxy)-3,5-dimethoxy-phenylacetylene + 3,4,5-trimethoxybenzaldehyde oxime (39201-89-3) → 5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole (1272644-68-4)

Guidance literature:

With sodium hypochlorite; triethylamine; In dichloromethane; water; at 0 - 20 ℃; for 25h; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.12.004

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole (1272644-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / 6 h / 20 °C

2: sodium hypochlorite; triethylamine / dichloromethane; water / 25 h / 0 - 20 °C / Inert atmosphere

With sodium hypochlorite; hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; In dichloromethane; water;

DOI:10.1016/j.ejmech.2010.12.004

Reference yield: 60.0%

5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole (1272644-68-4) → 2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenol (1227741-05-0)

Guidance literature:

5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

With water; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.ejmech.2010.12.004

upstream raw materials:

3,4,5-trimethoxybenzaldehyde oxime

3,4,5-trimethoxy-benzaldehyde

Downstream raw materials:

2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenol

2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one