2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 1272644-91-3
• Molecular Formula: C₃₉H₄₁N₃O₁₀
• Molecular Weight: 711.769
• Mol file: 1272644-91-3.mol

Synonyms:2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 7 articles about 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenol (1227741-05-0) + 2-(3-(4-bromobutoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1272644-81-1) → 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1272644-91-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2010.12.004

Reference yield:

isovanillin (621-59-0) → 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1272644-91-3)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / N,N-dimethyl acetamide / 2 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.12.004

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1272644-91-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / 6 h / 20 °C

2.1: sodium hypochlorite; triethylamine / dichloromethane; water / 25 h / 0 - 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.2: 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium hypochlorite; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.12.004

upstream raw materials:

isovanillin

2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenol

2-(3-(4-bromobutoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

5-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)isoxazole