(RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

Base Information

Chemical Name:(RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol
CAS No.:351529-75-4
Molecular Formula:C₂₁H₃₄N₄O₂Si
Molecular Weight:402.612
Hs Code.:

Synonyms:(RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

Suppliers and Price of (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

There total 1 articles about (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 6086-21-1
1-methyl-1H-1,2,4-triazole

: 156440-98-1
(2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde

: 351529-75-4
(RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

Guidance literature:: at -78 - 20 ℃;
DOI:10.1016/S0960-894X(97)00230-8

Reference yield:

: 351529-75-4
(RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

: 156441-92-8
(2R,4S)-1-Allyloxycarbonyl-4-benzoylthio-2-(1-methyl-1, 2,4-triazol-5-ylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: HCO₂NH₄ / Pd/C / methanol / 0.67 h / Heating

2: 5.96 g / aq. NaOH / tetrahydrofuran / 0.17 h / 0 - 5 °C / pH 8.5 - 10

3: pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

4: 2.69 g / AIBN; n-Bu₃SnH / toluene / 3.5 h / Heating

5: aq. HCl / methanol / 1.75 h / 0 - 20 °C

6: PPh₃; DEAD / tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; ammonium formate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; 6: Mitsunobu reaction;
DOI:10.1016/S0968-0896(00)00314-X

Reference yield:

: 351529-75-4
(RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-1,2,4-triazol-5-yl)methanol

: (2S,4R)-1-Allyloxycarbonyl-4-t-butyldimethylsilyloxy-2-{1-(1-methyl-1,2,4-triazol-5-yl)-1-(phenoxythiocarbonyloxy) methyl}pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: HCO₂NH₄ / Pd/C / methanol / 0.67 h / Heating

2: 5.96 g / aq. NaOH / tetrahydrofuran / 0.17 h / 0 - 5 °C / pH 8.5 - 10

3: pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

With pyridine; sodium hydroxide; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(00)00314-X