6086-21-1Relevant articles and documents
Novel spectrophotometric methods for the determination of fluconazole in the presence of its oxidative degradation product
Lotfy, Hayam Mahmoud,Monir, Hany Hunter,Abd El-Aleem, Abd El-Aziz El-Bayoumi
, p. 1447 - 1455 (2013/07/19)
Five sensitive, selective and precise spectrophotometric stability-indicating methods for the determination of fluconazole in the presence of its oxidative degradation product and in pharmaceutical formulations are developed and validated. Method A is a newly developed spectrophotometric one that is called ratio difference method by measuring the difference in amplitudes between 261.5 and 266.5 nm of ratio spectrum. Method B is a third derivative spectrophotometric one, which determines peak amplitudes from 265.5-268nm (peak-peak). Method C is ratio subtraction method. Method D is the first derivative of the ratio spectra by measuring the peak amplitude at 269 nm. Finally, method E is the mean centering of ratio spectra method by measuring the peak amplitude at 266.5 nm. The proposed methods allow the determination of fluconazole in the presence of its oxidative degradation product over a concentration range of 50-400 μg.mL-1 with mean percentage recoveries of 100.24±0.91, 99.91±0.52, 100.20±1.26, 99.79±0.69, and 100.77±0.72 respectively. The selectivity of the proposed methods is checked using laboratory prepared mixtures. The proposed methods have been successfully applied to the analysis of fluconazole in pharmaceutical dosage forms without interference from other dosage form additives and the results have been statistically compared with a reported method.
An investigation into the alkylation of 1,2,4-triazole
Bulger, Paul G.,Cottrell, Ian F.,Cowden, Cameron J.,Davies, Antony J.,Dolling, Ulf-H.
, p. 1297 - 1301 (2007/10/03)
The alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Previously reported regiospecific alkylations of 1,2,4-triazole were re-examined and the quoted isomer ratios were shown to depend on the isolation procedure. The use of DBU as base in the alkylation of 1,2,4-triazole allows for a convenient and high yielding synthesis of 1- substituted-1,2,4-triazoles. (C) 2000 Elsevier Science Ltd.
Oxidative Alkylation of Azoles. III. Reaction of N-Chloro-1,2,4-triazole with Methyl Iodide
Kurenkov, A. A.,Pevzner, M. S.
, p. 1118 - 1121 (2007/10/03)
Reaction of 1-chloro-1,2,4-triazole with methyl iodide in methylene chloride or chloroform at 20-40 deg C results in formation of products of mono- and dialkylation of the ring at positions 1 and 4.Under the same conditions, the 1,4-dimethyltriazolium salt gives rise to 5-iodo derivative.
