methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Chemical Name:methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate
CAS No.:1265402-09-2
Molecular Formula:C₂₅H₃₅N₃O₂
Molecular Weight:409.572
Hs Code.:

Synonyms:methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Chemical Property of methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Technology Process of methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

There total 7 articles about methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 15501-33-4
neopentyl iodide

: 1265400-26-7
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

: 1265402-09-2
methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate; With potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; at -15 ℃; for 0.25h;

neopentyl iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; at -15 - 20 ℃; for 5h;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265402-09-2
methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

3.1: potassium hexamethylsilazane / N,N-dimethyl-formamide; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran / 0.25 h / -15 °C

3.2: 5 h / -15 - 20 °C

With potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1265402-09-2
methyl 4,4-dimethyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 18 h / Reflux

1.2: 0 °C

2.1: water; chloroacetic acid / 24 h / Reflux

3.1: thionyl chloride / 12 h / 0 °C / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

6.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

7.1: potassium hexamethylsilazane / N,N-dimethyl-formamide; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran / 0.25 h / -15 °C

7.2: 5 h / -15 - 20 °C

With thionyl chloride; water; sodium methylate; potassium hexamethylsilazane; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; chloroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;