MRT-83

Base Information

• Chemical Name: MRT-83
• CAS No.: 1263131-92-5
• Molecular Formula: C₃₁H₃₀N₄O₅
• Molecular Weight: 538.603
• Mol file: 1263131-92-5.mol

Synonyms:MRT-83

Chemical Property of MRT-83

Chemical Property:

• Density: 1.22±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

MRT-83 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: MRT-83 is a novel potent antagonist of SMO, which has been shown to be useful for manipulating Hh signaling and may help develop new therapies against Hh-pathway related diseases.

Technology Process of MRT-83

There total 8 articles about MRT-83 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

MRT-81 (1263132-08-6) → MRT-83 (1263131-92-5)

Guidance literature:

MRT-81; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere; Cooling with ice;

With hydrogenchloride; In diethyl ether; ethyl acetate; Inert atmosphere;

DOI:10.1021/jm2013369

Reference yield:

N-(2-methyl-5-nitrophenyl)-[1,1’-biphenyl]-4-carboxamide (304452-55-9) → MRT-83 (1263131-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / Inert atmosphere; Microwave irradiation

2.1: acetone / 1 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere

With palladium 10% on activated carbon; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In isopropyl alcohol; acetone; acetonitrile;

DOI:10.1021/jm2013369

Reference yield:

N-(5-amino-2-methylphenyl)-[1,1’-biphenyl]-4-carboxamide (1245533-64-5) → MRT-83 (1263131-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetone / 1 h / Inert atmosphere; Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetone; acetonitrile;

DOI:10.1021/jm2013369

upstream raw materials:

N-(2-methyl-5-nitrophenyl)-[1,1’-biphenyl]-4-carboxamide

N-(5-amino-2-methylphenyl)-[1,1’-biphenyl]-4-carboxamide

MRT-81

3,4,5-Trimethoxybenzoyl chloride