N-(2-methyl-5-nitrophenyl)-4-biphenylcarboxamide

Base Information

• Chemical Name: N-(2-methyl-5-nitrophenyl)-4-biphenylcarboxamide
• CAS No.: 304452-55-9
• Molecular Formula: C₂₀H₁₆N₂O₃
• Molecular Weight: 332.359
• Mol file: 304452-55-9.mol

Synonyms:N-(2-methyl-5-nitrophenyl)-[1,1’-biphenyl]-4-carboxamide

Chemical Property of N-(2-methyl-5-nitrophenyl)-4-biphenylcarboxamide

Chemical Property:

Purity/Quality:

N-(2-methyl-5-nitrophenyl)-4-biphenylcarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methyl-5-nitrophenyl)-4-biphenylcarboxamide

There total 1 articles about N-(2-methyl-5-nitrophenyl)-4-biphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-biphenyl-carboxylic acid chloride (14002-51-8) + 2-methyl-5-nitroaniline (99-55-8) → N-(2-methyl-5-nitrophenyl)-[1,1’-biphenyl]-4-carboxamide (304452-55-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 66.0%

N-(2-methyl-5-nitrophenyl)-[1,1’-biphenyl]-4-carboxamide (304452-55-9) → N-(5-amino-2-methylphenyl)-[1,1’-biphenyl]-4-carboxamide (1245533-64-5)

Guidance literature:

With tin(II) chloride hydrate; In ethanol; at 80 ℃; for 2h;

Reference yield:

N-(2-methyl-5-nitrophenyl)-[1,1’-biphenyl]-4-carboxamide (304452-55-9) → MRT-83 (1263131-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / Inert atmosphere; Microwave irradiation

2.1: acetone / 1 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere

With palladium 10% on activated carbon; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In isopropyl alcohol; acetone; acetonitrile;

DOI:10.1021/jm2013369

upstream raw materials:

4-biphenyl-carboxylic acid chloride

2-methyl-5-nitroaniline

Downstream raw materials:

MRT-83

N-(5-amino-2-methylphenyl)-[1,1’-biphenyl]-4-carboxamide

MRT-81