Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

Base Information

Chemical Name:Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate
CAS No.:169612-46-8
Molecular Formula:C₂₁H₃₄N₂O₆Si
Molecular Weight:438.596
Hs Code.:

Synonyms:Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

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Chemical Property of Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

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Technology Process of Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

There total 1 articles about Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 19542-34-8
N-(benzyloxycarbonyl)-L-alanyl-L-serine methyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 169612-46-8
Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

Guidance literature:: With 1H-imidazole;
DOI:10.1016/0040-4039(95)00743-V

Reference yield:

: 169612-46-8
Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

: (3S,6S)-1,4-Diacetyl-3-cyclohexylmethyl-6-methylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / H₂, Et₃N / 10 percent Pd/C / methanol / 16 h / Ambient temperature

2: 86 percent / 4 h / Heating

3: 80 percent / FeCl₃ / Heating

4: 70 percent / Et₃N / CH₂Cl₂

5: 49 percent / NaBH₄, H₂O / CH₂Cl₂

With sodium tetrahydroborate; water; hydrogen; iron(III) chloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/a900771g

Reference yield:

: 169612-46-8
Methyl N-(N-benzyloxycarbonyl-L-alanyl)-O-tert-butyldimethylsilyl-L-serinate

: (3S,6S)-1,4-Diacetyl-3-methyl-6-phenethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / H₂, Et₃N / 10 percent Pd/C / methanol / 16 h / Ambient temperature

2: 86 percent / 4 h / Heating

3: 80 percent / FeCl₃ / Heating

4: 70 percent / Et₃N / CH₂Cl₂

5: 63 percent / Bu₃SnH, AIBN / benzene / Ambient temperature; Irradiation

With 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; iron(III) chloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; benzene;
DOI:10.1039/a900771g