2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

Base Information

Chemical Name:2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate
CAS No.:137334-72-6
Molecular Formula:C₅₁H₄₈Cl₆O₃
Molecular Weight:921.658
Hs Code.:

2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzo<a,d,g>cyclononene racemate

Synonyms:2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

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Chemical Property of 2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

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Technology Process of 2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

There total 4 articles about 2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 137334-71-5
2,7,12-tris<<3,5-bis(methoxymethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimthoxy-5H-tribenzocyclononene racemate

: 137334-72-6
2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

Guidance literature:: With boron trichloride; In dichloromethane; at 25 ℃; for 0.25h;
DOI:10.1021/jo00027a011

Reference yield:

: 137334-69-1
1-bromo-3,5-bis(methoxymethyl)benzene

: 137334-72-6
2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexanes, -78 deg C, 2 min, 2.) to 25 deg C

2: 1.) n-BuLi / 1.) TFH, hexanes, -78 deg C, 5 min, 2.) THF, to 25 deg C

3: Et₃SiH, trifluoroacetic acid / CH₂Cl₂ / 2 h / 25 °C

4: 75 percent / BCl₃ / CH₂Cl₂ / 0.25 h / 25 °C

With triethylsilane; n-butyllithium; boron trichloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo00027a011

Reference yield:

: 137334-70-4
3,5-bis(methoxymethyl)benzaldehyde

: 137334-72-6
2,7,12-tris<<3,5-bis(chloromethyl)phenyl>methyl>-10,15-dihydro-3,8,13-trimethoxy-5H-tribenzocyclononene racemate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) TFH, hexanes, -78 deg C, 5 min, 2.) THF, to 25 deg C

2: Et₃SiH, trifluoroacetic acid / CH₂Cl₂ / 2 h / 25 °C

3: 75 percent / BCl₃ / CH₂Cl₂ / 0.25 h / 25 °C

With triethylsilane; n-butyllithium; boron trichloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo00027a011