C₂₃H₂₂FN₃O₂S

Base Information

Chemical Name:C₂₃H₂₂FN₃O₂S
CAS No.:1552321-13-7
Molecular Formula:C₂₃H₂₂FN₃O₂S
Molecular Weight:423.511
Hs Code.:

C<sub>23</sub>H<sub>22</sub>FN<sub>3</sub>O<sub>2</sub>S

Synonyms:C₂₃H₂₂FN₃O₂S

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Chemical Property of C₂₃H₂₂FN₃O₂S

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Technology Process of C₂₃H₂₂FN₃O₂S

There total 6 articles about C₂₃H₂₂FN₃O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1552320-66-7
ethyl 2-[4-[(2-chloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetate

: 1993-03-9
o-fluorophenylboronic acid

: 1552321-13-7
C₂₃H₂₂FN₃O₂S

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; water; at 130 ℃; for 0.833333h; Microwave irradiation;
DOI:10.1016/j.bmcl.2013.12.076

Reference yield:

: 38555-40-7
methyl 4-{[2-(methyloxy)-2-oxoethyl]thio}butanoate

: 1552321-13-7
C₂₃H₂₂FN₃O₂S

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / toluene / 3 h / 105 °C

2: potassium hydroxide / methanol / 16 h / 20 °C

3: water; acetic acid / 72 h / 110 °C

4: N,N-dimethyl-aniline; trichlorophosphate / 18 h / 90 °C

5: N-ethyl-N,N-diisopropylamine / ethanol / 65 h / Reflux

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 0.83 h / 130 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium methylate; sodium carbonate; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In methanol; 1,2-dimethoxyethane; ethanol; water; toluene; 1: |Dieckmann Condensation / 6: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.12.076

Reference yield:

: 38555-41-8
methyl 3-oxo-2,3,4,5-tetrahydro-6H-thiopyran-2-carboxylate

: 1552321-13-7
C₂₃H₂₂FN₃O₂S

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / 16 h / 20 °C

2: water; acetic acid / 72 h / 110 °C

3: N,N-dimethyl-aniline; trichlorophosphate / 18 h / 90 °C

4: N-ethyl-N,N-diisopropylamine / ethanol / 65 h / Reflux

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane; water / 0.83 h / 130 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In methanol; 1,2-dimethoxyethane; ethanol; water; 5: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.12.076