Technology Process of (S)-ethyl 2-(dibenzylamino)-2-[(1,3-dioxoisoindolin-2-yl)methyl]propanoate
There total 5 articles about (S)-ethyl 2-(dibenzylamino)-2-[(1,3-dioxoisoindolin-2-yl)methyl]propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetonitrile;
for 12h;
Inert atmosphere;
Reflux;
DOI:10.1039/c3ob41282b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 1.5 h / 0 - 20 °C
1.2: 12 h / Reflux
2.1: pig liver esterase / aq. phosphate buffer; ethanol / pH 7.4 / Enzymatic reaction
3.1: triethylamine; diphenyl phosphoryl azide / 1,2-dichloro-ethane / 3.5 h / 20 °C / Inert atmosphere; Reflux
3.2: 12 h / Reflux; Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 1 h
5.1: potassium carbonate / acetonitrile / 12 h / Inert atmosphere; Reflux
With
pig liver esterase; diphenyl phosphoryl azide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; mineral oil;
3.2: |Curtius Rearrangement;
DOI:10.1039/c3ob41282b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 1.5 h / 0 - 20 °C
1.2: 12 h / Reflux
2.1: pig liver esterase / aq. phosphate buffer; ethanol / pH 7.4 / Enzymatic reaction
3.1: triethylamine; diphenyl phosphoryl azide / 1,2-dichloro-ethane / 3.5 h / 20 °C / Inert atmosphere; Reflux
3.2: 12 h / Reflux; Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 1 h
5.1: potassium carbonate / acetonitrile / 12 h / Inert atmosphere; Reflux
With
pig liver esterase; diphenyl phosphoryl azide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; aq. phosphate buffer; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; mineral oil;
3.2: |Curtius Rearrangement;
DOI:10.1039/c3ob41282b
