3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

Base Information

Chemical Name:3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS No.:1280200-39-6
Molecular Formula:C₂₅H₂₂F₆N₄O₂
Molecular Weight:524.466
Hs Code.:

Synonyms:3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

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Chemical Property of 3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

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Technology Process of 3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

There total 7 articles about 3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1280201-02-6
tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1280200-39-6
3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

Guidance literature:: tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 2h;

With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 40 ℃; for 1h;

3,5-Bis-(trifluoromethyl)aniline; In tetrahydrofuran; at 40 ℃; for 2h;

Reference yield:

: 87-62-7
2,6-dimethylaniline

: 1280200-39-6
3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 0.75 h / 130 °C

2.1: dmap; triethylamine; 2,4,6-trichlorobenzoyl chloride / dichloromethane / 14 h / 10 - 20 °C / Cooling with ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / 0 - 20 °C

4.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 18 h / 20 °C

5.1: sodium periodate / water; tetrahydrofuran / 20 °C

6.1: ammonium acetate; acetic acid / tetrahydrofuran; methanol / 40 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C

7.2: 1 h / 40 °C

7.3: 2 h / 40 °C

With hydrogenchloride; dmap; sodium periodate; osmium(VIII) oxide; 2,4,6-trichlorobenzoyl chloride; ammonium acetate; water; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 1280201-01-5
tert-butyl 1-(2,6-dimethylphenyl)-5-oxo-3-(2-oxoethyl)pyrrolidine-3-carboxylate

: 1280200-39-6
3-((1H-imidazol-2-yl)methyl)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / tetrahydrofuran; methanol / 40 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C

2.2: 1 h / 40 °C

2.3: 2 h / 40 °C

With hydrogenchloride; ammonium acetate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol;