tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS No.:1280201-02-6
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

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Chemical Property of tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

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Technology Process of tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

There total 6 articles about tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1280201-01-5
tert-butyl 1-(2,6-dimethylphenyl)-5-oxo-3-(2-oxoethyl)pyrrolidine-3-carboxylate

: 4405-13-4
glyoxal trimer dihydrate

: 1280201-02-6
tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

Guidance literature:: With ammonium acetate; acetic acid; In tetrahydrofuran; methanol; at 40 ℃;

Reference yield:

: 87-62-7
2,6-dimethylaniline

: 1280201-02-6
tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.75 h / 130 °C

2.1: dmap; triethylamine; 2,4,6-trichlorobenzoyl chloride / dichloromethane / 14 h / 10 - 20 °C / Cooling with ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / 0 - 20 °C

4.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 18 h / 20 °C

5.1: sodium periodate / water; tetrahydrofuran / 20 °C

6.1: ammonium acetate; acetic acid / tetrahydrofuran; methanol / 40 °C

With dmap; sodium periodate; osmium(VIII) oxide; 2,4,6-trichlorobenzoyl chloride; ammonium acetate; water; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 1280200-99-8
tert-butyl 3-(2,3-dihydroxypropyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

: 1280201-02-6
tert-butyl 3-((1H-imidazol-2-yl)methyl)-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / water; tetrahydrofuran / 20 °C

2: ammonium acetate; acetic acid / tetrahydrofuran; methanol / 40 °C

With sodium periodate; ammonium acetate; acetic acid; In tetrahydrofuran; methanol; water;