(3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

Base Information

Chemical Name:(3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]
CAS No.:634203-87-5
Molecular Formula:C₃₄H₃₈N₄O₈
Molecular Weight:630.698
Hs Code.:

Synonyms:(3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

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Chemical Property of (3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

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Technology Process of (3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

There total 3 articles about (3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 146803-45-4
N-(fluorenylmethyloxycarbonyl)-L-aspart-α-al β-tert-butyl ester

: semicarbazidyl-4-[2'-(4-ethyl-phenoxyacetic acid)]hydrochloride

: 634203-87-5
(3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

Guidance literature:: With sodium acetate; In ethanol; at 0 ℃; for 16h;
DOI:10.1016/S0960-894X(02)00629-7

Reference yield:

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 634203-87-5
(3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / HOBt; EDAC; NMM / tetrahydrofuran / 0 °C

2: LAH / diethyl ether / 1 h / 0 °C

3: 69 percent / NaOAc / ethanol / 16 h / 0 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; sodium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/S0960-894X(02)00629-7

Reference yield:

: 204973-60-4
N-(9-fluorenylmethoxycarbonyl)-N’-methoxy-N’-methyl-L-isoasparagine t-butyl ester

: 634203-87-5
(3S)-3-(9-fluorenylmethoxycabonyl)amino-4-oxobutanoic acid tert-butyl ester semicarbazonyl-4-[2'-(4-ethyl-phenoxyacetic acid)]

Guidance literature:: Multi-step reaction with 2 steps

1: LAH / diethyl ether / 1 h / 0 °C

2: 69 percent / NaOAc / ethanol / 16 h / 0 °C

With lithium aluminium tetrahydride; sodium acetate; In diethyl ether; ethanol;
DOI:10.1016/S0960-894X(02)00629-7