N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester

Base Information

• Chemical Name: N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester
• CAS No.: 159236-36-9
• Molecular Formula: C₂₉H₃₁N₃O₆
• Molecular Weight: 517.582
• Mol file: 159236-36-9.mol

Synonyms:N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester

Chemical Property of N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester

There total 2 articles about N^α-dinicotinoyl-bis-L-phenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

pyridine-3,5-dicarbonyl dichloride (15074-61-0) + (L)-phenylalanine ethyl ester hydrochloride (3182-93-2) → Nα-dinicotinoyl-bis-L-phenylalanine ethyl ester (159236-36-9)

Guidance literature:

With triethylamine; In dichloromethane; benzene; at -5 ℃; for 3h; pH 8;

DOI:10.1135/cccc19941451

Reference yield:

3,5-Pyridinedicarboxylic acid (499-81-0) → Nα-dinicotinoyl-bis-L-phenylalanine ethyl ester (159236-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dioxane / 1 h / Heating

2: 67 percent / Et₃N / benzene; CH₂Cl₂ / 3 h / -5 °C / pH 8

With thionyl chloride; triethylamine; In 1,4-dioxane; dichloromethane; benzene;

DOI:10.1135/cccc19941451

Reference yield: 53.0%

Nα-dinicotinoyl-bis-L-phenylalanine ethyl ester (159236-36-9) → N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid] (159236-37-0)

Guidance literature:

With potassium hydroxide; In methanol; at -5 ℃; for 3h;

DOI:10.1135/cccc19941451

upstream raw materials:

pyridine-3,5-dicarbonyl dichloride

(L)-phenylalanine ethyl ester hydrochloride

3,5-Pyridinedicarboxylic acid

Downstream raw materials:

N,N'-(pyridine-3,5-diyldicarbonyl)bis[(2S)-2-amino-3-phenylpropanoic acid]