(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Base Information

Chemical Name:(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine
CAS No.:148432-29-5
Molecular Formula:C₄₁H₆₄N₂O₆
Molecular Weight:680.969
Hs Code.:

(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Synonyms:(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

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Chemical Property of (S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

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Technology Process of (S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

There total 6 articles about (S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3587-60-8
Benzyloxymethyl chloride

: 148432-20-6
(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

: 148432-29-5
(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Heating;

Reference yield:

: 145656-72-0
2,6-di-tert-butyl-4-methoxyphenyl pyruvate

: 148432-29-5
(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / p-TsOH / cyclohexane / 20 h / Heating

2: LDA, LiBr / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) -90 deg C, 2 h; -78 deg C, 1 h

3: 93 percent / iPr₂NEt, n-Bu₄NI / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane;

Reference yield:

: 148432-21-7
(S)-(+)-1-[1-(2,6-Di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-ethylideneamino]-2-(1-methoxy-1-ethylpropyl)pyrrolidine

: 148432-29-5
(S,R)-(+)-1-[3-O-Benzyloxymethyl-3-hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxyphenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: LDA, LiBr / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) -90 deg C, 2 h; -78 deg C, 1 h

2: 93 percent / iPr₂NEt, n-Bu₄NI / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;