(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Base Information

Chemical Name:(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine
CAS No.:148432-20-6
Molecular Formula:C₃₃H₅₆N₂O₅
Molecular Weight:560.818
Hs Code.:

Synonyms:(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

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Chemical Property of (S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

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Technology Process of (S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

There total 5 articles about (S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145656-72-0
2,6-di-tert-butyl-4-methoxyphenyl pyruvate

: 148432-20-6
(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / p-TsOH / cyclohexane / 20 h / Heating

2: LDA, LiBr / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) -90 deg C, 2 h; -78 deg C, 1 h

With toluene-4-sulfonic acid; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane;

Reference yield:

: 148432-21-7
(S)-(+)-1-[1-(2,6-Di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-ethylideneamino]-2-(1-methoxy-1-ethylpropyl)pyrrolidine

: 590-86-3
isovaleraldehyde

: 148432-20-6
(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

: (S,S)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Guidance literature:: With lithium bromide; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h;

Reference yield:

: 489-01-0
2,6-Di-t-butyl-4-methoxyphenol

: 148432-20-6
(S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: n-BuLi / tetrahydrofuran / 0 °C

2: diethyl ether / -78 °C

3: 83 percent / p-TsOH / cyclohexane / 20 h / Heating

4: LDA, LiBr / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) -90 deg C, 2 h; -78 deg C, 1 h

With n-butyllithium; toluene-4-sulfonic acid; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; cyclohexane;