4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Base Information

Chemical Name:4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole
CAS No.:1188301-87-2
Molecular Formula:C₁₄H₈BrClF₃N₃O
Molecular Weight:406.589
Hs Code.:

Synonyms:4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Suppliers and Price of 4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

There total 4 articles about 4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1391766-54-3
5-bromo-2-(4-(trifluoromethyl)phenyl)oxazole

: 1188301-87-2
4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: 5-bromo-2-(4-(trifluoromethyl)phenyl)oxazole; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 2.5h;

2-chloropyrimidine; In tetrahydrofuran; n-heptane; ethylbenzene; at 10 ℃; for 1.5h;

Reference yield:

: 286367-11-1
2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole

: 1188301-87-2
4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2.5 h / -78 °C

2.2: 1.5 h / 10 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; n-heptane; ethylbenzene;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1188301-87-2
4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 18 h / 0 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2.5 h / -78 °C

3.2: 1.5 h / 10 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triethylamine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; n-heptane; dichloromethane; ethylbenzene;