4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Base Information

Chemical Name:4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole
CAS No.:1188301-86-1
Molecular Formula:C₁₄H₆BrClF₃N₃O
Molecular Weight:404.573
Hs Code.:

Synonyms:4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

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Chemical Property of 4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Chemical Property:

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Technology Process of 4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

There total 5 articles about 4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188301-87-2
4-bromo-5-(2-chloro-4,5-dihydropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

: 1188301-86-1
4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: With manganese(IV) oxide; In ethyl acetate; at 110 ℃; Microwave irradiation;

Reference yield:

: 286367-11-1
2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole

: 1188301-86-1
4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2.5 h / -78 °C

2.2: 1.5 h / 10 °C

3.1: manganese(IV) oxide / ethyl acetate / 110 °C / Microwave irradiation

With manganese(IV) oxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; n-heptane; ethylbenzene; ethyl acetate;

Reference yield:

: 1391766-54-3
5-bromo-2-(4-(trifluoromethyl)phenyl)oxazole

: 1188301-86-1
4-bromo-5-(2-chloropyrimidin-4-yl)-2-(4-(trifluoromethyl)phenyl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2.5 h / -78 °C

1.2: 1.5 h / 10 °C

2.1: manganese(IV) oxide / ethyl acetate / 110 °C / Microwave irradiation

With manganese(IV) oxide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; ethyl acetate;