(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

Base Information

Chemical Name:(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol
CAS No.:853061-30-0
Molecular Formula:C₃₁H₃₇FO₃Si
Molecular Weight:504.717
Hs Code.:

Synonyms:(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

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Chemical Property of (E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

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Technology Process of (E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

There total 12 articles about (E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 853061-29-7
(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-enoic acid ethyl ester

: 853061-30-0
(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1139/v05-259

Reference yield:

: 853061-12-8
2-(3-hydroxy-propyl)-4-methoxy-benzaldehyde

: 853061-30-0
(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / imidazole / tetrahydrofuran / 0.75 h / 20 °C

2: 97 percent / sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

3: 97 percent / diisobutylaluminium hydride / CH₂Cl₂ / 1 h / 0 °C

4: 93 percent / imidazole / tetrahydrofuran / 1.5 h / 20 °C

5: 98 percent / p-toluenesulfonate pyridinium salt / ethanol / 20 °C

6: 100 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 3 h / 20 °C

7: 93 percent / n-butyl lithium / hexane; tetrahydrofuran / 0.75 h / -78 °C

8: 100 percent / lithium aluminium hydride / tetrahydrofuran / 0.33 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; 2: Horner-Emmons reaction / 6: Swern oxidation / 7: Horner-Emmons reaction;
DOI:10.1139/v05-259

Reference yield:

: 853061-14-0
2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-benzaldehyde

: 853061-30-0
(E)-5-{2-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-5-methoxy-phenyl}-2-fluoro-pent-2-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

2: 97 percent / diisobutylaluminium hydride / CH₂Cl₂ / 1 h / 0 °C

3: 93 percent / imidazole / tetrahydrofuran / 1.5 h / 20 °C

4: 98 percent / p-toluenesulfonate pyridinium salt / ethanol / 20 °C

5: 100 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 3 h / 20 °C

6: 93 percent / n-butyl lithium / hexane; tetrahydrofuran / 0.75 h / -78 °C

7: 100 percent / lithium aluminium hydride / tetrahydrofuran / 0.33 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; 1: Horner-Emmons reaction / 5: Swern oxidation / 6: Horner-Emmons reaction;
DOI:10.1139/v05-259