1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

Base Information

Chemical Name:1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea
CAS No.:1419601-17-4
Molecular Formula:C₂₁H₂₄ClN₅O₂
Molecular Weight:413.907
Hs Code.:

Synonyms:1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

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Chemical Property of 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

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Technology Process of 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

There total 6 articles about 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1419604-45-7
1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-((tert-butyldimethylsilyloxy)methyl)pyridin-3-yl)urea

: 1419601-17-4
1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 22h;

Reference yield:

: 24242-19-1
5-aminonicotinic acid

: 1419601-17-4
1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 0 °C / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 23 °C / Inert atmosphere

3: 1H-imidazole / dichloromethane / 5 h / 23 °C

4: pyridine / tetrahydrofuran; acetonitrile / 1 h / 23 °C

5: dmap / acetonitrile / 50 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / 23 °C

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; thionyl chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 17285-76-6
5-aminonicotinic acid ethyl ester

: 1419601-17-4
1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 23 °C / Inert atmosphere

2: 1H-imidazole / dichloromethane / 5 h / 23 °C

3: pyridine / tetrahydrofuran; acetonitrile / 1 h / 23 °C

4: dmap / acetonitrile / 50 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / 23 °C

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;