N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Base Information

Chemical Name:N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide
CAS No.:1005194-71-7
Molecular Formula:C₂₄H₂₃N₅O
Molecular Weight:397.48
Hs Code.:

Synonyms:N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

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Chemical Property of N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Chemical Property:

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Technology Process of N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

There total 9 articles about N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005194-69-3
N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(piperidin-4-ylidene)acetamide

: 74-88-4
methyl iodide

: 1005194-71-7
N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 193085-24-4
4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester

: 1005194-71-7
N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 °C

2.1: dichloromethane / 2 h / 20 °C

3.1: sodium carbonate / water; ethyl acetate

4.1: potassium carbonate / acetonitrile / 24 h / 20 °C

With 4-methyl-morpholine; sodium carbonate; potassium carbonate; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 183321-64-4
N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine

: 1005194-71-7
N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; acetic acid / ethanol; water / 1 h / Heating / reflux

1.2: 20 °C

1.3: pH 9

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

2.2: 0 °C

3.1: dichloromethane / 2 h / 20 °C

4.1: sodium carbonate / water; ethyl acetate

5.1: potassium carbonate / acetonitrile / 24 h / 20 °C

With 4-methyl-morpholine; iron; sodium carbonate; potassium carbonate; acetic acid; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;