5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

Base Information

Chemical Name:5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide
CAS No.:1403258-69-4
Molecular Formula:C₂₆H₃₇BrN₄O₂
Molecular Weight:517.509
Hs Code.:

Synonyms:5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

There total 1 articles about 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.71%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1403258-67-2
3-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

: 1403258-69-4
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

Guidance literature:: formaldehyd; 3-(((1R,4R)-4-aminocyclohexyl)(ethyl)amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide; In dichloromethane; at 0 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 30.0%

: 1403258-69-4
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

: 5720-05-8
4-methylphenylboronic acid

: 76-05-1
trifluoroacetic acid

: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(((1r,4r)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-4,4'-dimethyl-[1,1'-biphenyl]-3-carboxamide trifluoroacetate

Guidance literature:: 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide; 4-methylphenylboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;

trifluoroacetic acid; Chromatography;

Reference yield: 27.0%

: 13331-23-2
fur-2-ylboronic acid

: 1403258-69-4
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide

: 76-05-1
trifluoroacetic acid

: (x)C₂HF₃O₂*C₃₀H₄₀N₄O₃

Guidance literature:: fur-2-ylboronic acid; 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(((1R,4R)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-2-methylbenzamide; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

trifluoroacetic acid; Preparative HPLC;