di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate

Base Information

Chemical Name:di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate
CAS No.:1532518-96-9
Molecular Formula:C₂₂H₃₁NO₈
Molecular Weight:437.49
Hs Code.:

Synonyms:di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate

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Technology Process of di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate

There total 2 articles about di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15241-32-4,21298-69-1,3316-24-3
1-methoxy-2-(2-nitrovinyl)benzene

: 86491-34-1
Di-tert-butyl α-ketoglutarate

: 1532518-96-9
di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate

: C₂₂H₃₁NO₈

Guidance literature:: With Ni(OAc)₂*(H₂O)₄-(S,S)-N,N’-dibenzylcyclohexane-1,2-diamine; triethylamine; In isopropyl alcohol; at 0 ℃; for 5h; Overall yield = 97 %; Overall yield = 5.39 g; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol403434e

Reference yield:

: 328-50-7
α-ketoglutaric acid

: 1532518-96-9
di-tert-butyl (S)-3-((S)-1-(2-methoxyphenyl)-2-nitroethyl)-2-oxopentanedioate

: C₂₂H₃₁NO₈

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; tert-butyl alcohol / 2 h / 20 °C

2: Ni(OAc)₂*(H₂O)₄-(S,S)-N,N’-dibenzylcyclohexane-1,2-diamine; triethylamine / isopropyl alcohol / 5 h / 0 °C / Inert atmosphere

With Ni(OAc)₂*(H₂O)₄-(S,S)-N,N’-dibenzylcyclohexane-1,2-diamine; triethylamine; In dichloromethane; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/ol403434e