3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

Base Information

Chemical Name:3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide
CAS No.:1380106-75-1
Molecular Formula:C₁₄H₁₃ClN₂O₃
Molecular Weight:292.722
Hs Code.:

Synonyms:3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

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Chemical Property of 3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

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Technology Process of 3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

There total 5 articles about 3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: C₁₉H₂₁ClN₂O₄

: 1380106-75-1
3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2012.04.019

Reference yield:

: 1380106-78-4
3-(4-bromo-2-chloro-phenyl)-acrylic acid methyl ester

: 1380106-75-1
3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 5 h / 86 °C

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.04.019

Reference yield:

: 158435-41-7
4-bromo-2-chlorobenzaldehyde

: 1380106-75-1
3-[2-chloro-4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-N-hydroxy-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h

1.2: 1 h

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 5 h / 86 °C

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1.2: Horner-Wadsworth-Emmons olefination / 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.04.019