N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Base Information

Chemical Name:N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide
CAS No.:1599475-00-9
Molecular Formula:C₁₈H₁₂F₂N₄OS₂
Molecular Weight:402.448
Hs Code.:

Synonyms:N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

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Chemical Property of N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

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Technology Process of N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

There total 5 articles about N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1599475-22-5
C₁₁H₁₀N₄S₂

: 18063-02-0
2,6-difluorobenzoylchloride

: 1599475-00-9
N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Guidance literature:: C₁₁H₁₀N₄S₂; 2,6-difluorobenzoylchloride; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1345118-93-5
1-Methyl-3-(1,3-thiazol-2-yl)pyrazol-5-yl boronic acid

: 1599475-00-9
N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: hydrogen; palladium on activated charcoal / methanol

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 166196-73-2,942223-95-2
2-(1H-pyrazol-3-yl)-1,3-thiazole

: 1599475-00-9
N-(2,6-difluorophenyl)-5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

1.2: 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C

2.2: -78 - 20 °C

2.3: 0.5 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol

5.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;