Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R,S)]-

Base Information

Chemical Name:Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R*,S*)]-
CAS No.:109960-56-7
Molecular Formula:C₁₃H₁₈ClN
Molecular Weight:223.746
Hs Code.:
DSSTox Substance ID:DTXSID301177089

Synonyms:DTXSID301177089;Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R*,S*)]-;109960-56-7

Suppliers and Price of Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R*,S*)]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R*,S*)]-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:223.1127773
Heavy Atom Count:15
Complexity:189

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)N2CCC(C2)CCl
Isomeric SMILES:C[C@H](C1=CC=CC=C1)N2CC[C@@H](C2)CCl

Technology Process of Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R*,S*)]-

There total 4 articles about Pyrrolidine, 3-(chloromethyl)-1-(1-phenylethyl)-, [R-(R*,S*)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 109960-55-6
(3S)-N-<(R)-phenylethyl>-3-(hydroxymethyl)pyrrolidine

: 109960-56-7
(3S)-1-<(R)-1-phenylethyl>-3-(chloromethyl)pyrrolidine

Guidance literature:: With thionyl chloride; In chloroform; for 2h; Heating;
DOI:10.1021/jm00163a012

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 109960-56-7
(3S)-1-<(R)-1-phenylethyl>-3-(chloromethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / 4 h / 160 °C

2: acetyl chloride / 16 h / Heating

3: 85 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating

4: 92 percent / thionyl chloride / CHCl₃ / 2 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; acetyl chloride; In diethyl ether; chloroform;
DOI:10.1021/jm00163a012

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 109960-56-7
(3S)-1-<(R)-1-phenylethyl>-3-(chloromethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / 4 h / 160 °C

2: acetyl chloride / 16 h / Heating

3: 85 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating

4: 92 percent / thionyl chloride / CHCl₃ / 2 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; acetyl chloride; In diethyl ether; chloroform;
DOI:10.1021/jm00163a012