(R)-3-PYRROLIDINEACETIC ACID HCL

Base Information

• Chemical Name: (R)-3-PYRROLIDINEACETIC ACID HCL
• CAS No.: 122442-01-7
• Molecular Formula: C6H11 N O2
• Molecular Weight: 129.159
• Mol file: 122442-01-7.mol

Synonyms:3-Pyrrolidineaceticacid, (R)-; (R)-Pyrrolidine-3-acetic acid

Chemical Property of (R)-3-PYRROLIDINEACETIC ACID HCL

Chemical Property:

• Vapor Pressure: 0.000221mmHg at 25°C
• Melting Point: 160-165 °C
• Refractive Index: ">
• Boiling Point: 303°Cat760mmHg
• PKA: 4.43±0.10(Predicted)
• Flash Point: 137.1°C
• PSA: 49.33000
• Density: g/cm³
• LogP: 1.20140

Purity/Quality:

98%min ^*data from raw suppliers

(R)-Pyrrolidine-3-aceticAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-PYRROLIDINEACETIC ACID HCL

There total 33 articles about (R)-3-PYRROLIDINEACETIC ACID HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(3R)-methyl 1-<(R)-1-phenylethyl>pyrrolidine-3-acetate hydrochloride (122408-85-9) → (R)-(-)-3-pyrrolidineacetic acid (122442-01-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 2205.2 Torr;

DOI:10.1021/jm00163a012

Reference yield: 58.0%

(3R)-2-(1-Benzylpyrrolidin-3-yl)acetic acid (216311-66-9) → (R)-(-)-3-pyrrolidineacetic acid (122442-01-7)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; for 16h; under 759.8 Torr; Ambient temperature;

DOI:10.1055/s-1998-2185

Reference yield: 53.0%

methyl (3R,1'S)-<1-(1'-phenyleth-1'-yl)-pyrrolidin-3-yl> acetate (174676-79-0) → (R)-(-)-3-pyrrolidineacetic acid (122442-01-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 2250.2 Torr;

DOI:10.1016/0957-4166(95)00423-8

upstream raw materials:

(3R)-methyl 1-<(R)-1-phenylethyl>pyrrolidine-3-acetate hydrochloride

methyl (3R,1'S)-<1-(1'-phenyleth-1'-yl)-pyrrolidin-3-yl> acetate

(3R)-2-(1-Benzylpyrrolidin-3-yl)acetic acid

ethyl (R)-(-)-3-pyrrolidineacetate

Downstream raw materials:

[(R)-1-(6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)pyrrolidin-3-yl]acetic acid

Refernces

• 1、 Thomas, Christoph,Orecher, Florian,Gmeiner, Peter. "A practical ex-chiral-pool synthesis of β-proline and homo-β-proline". . p. 1491 - 1496. Retrieved 2007/10/03.
• 2、 Galeazzi, Roberta,Mobbili, Giovanna,Orena, Mario. "A convenient approach to diastereomerically pure 1,3,4-trisubstituted pyrrolidin-2-ones by intramolecular cyclisation of N-(2-alken-1-yl)amides mediated by Mn(III). An entry to both (R)- and (S)-3-pyrrolidineacetic acid". . p. 1069 - 1084. Retrieved 2007/10/03.