5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Base Information

Chemical Name:5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester
CAS No.:68496-91-3
Molecular Formula:C₁₁H₈Cl₂N₂O₃
Molecular Weight:287.102
Hs Code.:

Synonyms:5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

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Chemical Property of 5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

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Technology Process of 5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

There total 4 articles about 5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91085-56-2
3,5-dichlorobenzoic acid ethyl ester

: 68496-91-3
5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / 12 h / 80 °C

2: triethylamine / dichloromethane / 9 h / -10 - 25 °C

With hydrazine hydrate; triethylamine; In dichloromethane;
DOI:10.1021/acs.jafc.1c00088

Reference yield:

: 4755-77-5
Ethyl oxalyl chloride

: 62899-78-9
3,5-dichlorobenzoic acid hydrazide

: 68496-91-3
5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Guidance literature:: Ethyl oxalyl chloride; 3,5-dichlorobenzoic acid hydrazide; With triethylamine; In dichloromethane; at -10 - 25 ℃; for 9h;

With triethylamine; p-toluenesulfonyl chloride; In ethanol;
DOI:10.1021/acs.jafc.1c00088

Reference yield:

: 2905-62-6
3,5-dichlorobenzoyl chloride

: 68496-91-3
5-(3,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 5 h / 60 °C

2: hydrazine hydrate / 12 h / 80 °C

3: triethylamine / dichloromethane / 9 h / -10 - 25 °C

With sulfuric acid; hydrazine hydrate; triethylamine; In dichloromethane;
DOI:10.1021/acs.jafc.1c00088