(4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
• CAS No.: 144512-26-5
• Molecular Formula: C₁₉H₂₈N₂O₄
• Molecular Weight: 348.442

Synonyms:(4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Chemical Property of (4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5R)-3-(tert-Butoxycarbonyl)-4-formyl-2,2,5-trimethyloxazolidine (108149-62-8) + 4-methoxy-aniline (104-94-9) → (4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (144512-26-5)

Guidance literature:

With magnesium sulfate; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1021/ja00050a016

Reference yield: 86.0%

Benzyloxyacetyl chloride (19810-31-2) + (4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (144512-26-5) → (4R,5R)-4-[(2R,3S)-3-Benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (144492-53-5)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ja00050a016

Reference yield: 50.0%

(4R,5R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (144512-26-5) + Acetoxyacetyl chloride (13831-31-7) → (4R,5R)-4-[(2R,3S)-3-Acetoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (144492-50-2)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ja00050a016

upstream raw materials:

(4S,5R)-3-(tert-Butoxycarbonyl)-4-formyl-2,2,5-trimethyloxazolidine

4-methoxy-aniline

Downstream raw materials:

(4R,5R)-4-[(2R,3S)-3-Benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(4R,5R)-4-[(2R,3S)-3-Acetoxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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