3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Base Information

Chemical Name:3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester
CAS No.:1054660-71-7
Molecular Formula:C₂₂H₂₈N₂O₆
Molecular Weight:416.474
Hs Code.:

Synonyms:3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

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Chemical Property of 3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

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Technology Process of 3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

There total 5 articles about 3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 852060-08-3
3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

: 5437-45-6
Benzyl bromoacetate

: 1054660-71-7
3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Guidance literature:: With caesium carbonate; In acetonitrile; at 50 ℃; for 2h;
DOI:10.1021/jo050146m

Reference yield:

: 852059-99-5
(S)-2-(1-Cyano-cyclohexylamino)-pentanedioic acid dimethyl ester

: 1054660-71-7
3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / sulfuric acid / CH₂Cl₂ / 1 h / 20 °C

2: 99 percent / Cs₂CO₃ / acetonitrile / 2 h / 50 °C

With sulfuric acid; caesium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/jo050146m

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1054660-71-7
3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / CH₂Cl₂ / 3 h / 20 °C

1.2: 70 percent / ytterbium triflate / CH₂Cl₂ / 21 h / -23 - 20 °C

2.1: 55 percent / sulfuric acid / CH₂Cl₂ / 1 h / 20 °C

3.1: 99 percent / Cs₂CO₃ / acetonitrile / 2 h / 50 °C

With sulfuric acid; caesium carbonate; triethylamine; In dichloromethane; acetonitrile; 1.2: Strecker reaction;
DOI:10.1021/jo050146m