Bz-Pro-Phe-NH₂

Base Information

• Chemical Name: Bz-Pro-Phe-NH₂
• CAS No.: 131458-37-2
• Molecular Formula: C₂₁H₂₃N₃O₃
• Molecular Weight: 365.432
• Mol file: 131458-37-2.mol

Synonyms:Bz-Pro-Phe-NH₂

Chemical Property of Bz-Pro-Phe-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bz-Pro-Phe-NH₂

There total 3 articles about Bz-Pro-Phe-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Bz-Pro-Phe-Ser-OMe (131458-25-8) → Bz-Pro-Phe-NH2 (131458-37-2)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; for 1.5h; Ambient temperature; pH 3;

DOI:10.1021/ja00094a008

Reference yield:

N-benzoyl-L-prolyl-L-phenylalanine (59191-06-9) → Bz-Pro-Phe-NH2 (131458-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / DCC, HOBt

2: 70 percent / NaIO₄, RuCl₃*3H₂O / acetonitrile; CCl₄ / 1.5 h / Ambient temperature; pH 3

With ruthenium trichloride; sodium periodate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrachloromethane; acetonitrile;

DOI:10.1021/ja00094a008

Reference yield:

iodobenzene (591-50-4) + carbon monoxide (201230-82-2) + Fmoc-L-Pro-L-Phe-OH → Bz-Pro-Phe-NH2 (131458-37-2)

Guidance literature:

Multistep reaction;

DOI:10.1016/S0040-4039(99)01667-6

upstream raw materials:

Bz-Pro-Phe-Ser-OMe

iodobenzene

carbon monoxide

N-benzoyl-L-prolyl-L-phenylalanine

Refernces

• 1、 Ranganathan,Vaish,Shah. "Protein backbone modification by novel C(α)-C side-chain scission". . p. 6545 - 6557. Retrieved 2007/10/02.