Technology Process of 2-[2-{3,4-bis(triisopropylsilyloxy)benzyloxy}-3-(methoxymethoxy)phenyl]acetic acid
There total 6 articles about 2-[2-{3,4-bis(triisopropylsilyloxy)benzyloxy}-3-(methoxymethoxy)phenyl]acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
diethyl ether; water; tert-butyl alcohol;
for 1.5h;
DOI:10.1055/s-0033-1340291
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 50 °C / Inert atmosphere
2: 18 h / 180 °C / Microwave irradiation; Inert atmosphere
3: diethylazodicarboxylate; triphenylphosphine / toluene; tetrahydrofuran; diethyl ether / 6 h / 0 - 20 °C / Inert atmosphere
4: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; diethyl ether; tert-butyl alcohol / 3 h / 0 - 20 °C
5: sodium periodate / water; diethyl ether / 6 h / 0 - 20 °C
6: 2-methyl-but-2-ene; sodium dihydrogenphosphate; sodium chlorite / water; diethyl ether; tert-butyl alcohol / 1.5 h
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; water; toluene; acetonitrile; tert-butyl alcohol;
2: |Claisen Rearrangement / 3: |Mitsunobu Displacement;
DOI:10.1055/s-0033-1340291
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 18 h / 180 °C / Microwave irradiation; Inert atmosphere
2: diethylazodicarboxylate; triphenylphosphine / toluene; tetrahydrofuran; diethyl ether / 6 h / 0 - 20 °C / Inert atmosphere
3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; diethyl ether; tert-butyl alcohol / 3 h / 0 - 20 °C
4: sodium periodate / water; diethyl ether / 6 h / 0 - 20 °C
5: 2-methyl-but-2-ene; sodium dihydrogenphosphate; sodium chlorite / water; diethyl ether; tert-butyl alcohol / 1.5 h
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; water; toluene; tert-butyl alcohol;
1: |Claisen Rearrangement / 2: |Mitsunobu Displacement;
DOI:10.1055/s-0033-1340291
