2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

Base Information

Chemical Name:2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride
CAS No.:1055962-39-4
Molecular Formula:C₁₃H₁₁ClN₂O₂*ClH
Molecular Weight:299.156
Hs Code.:

Synonyms:2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

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Chemical Property of 2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

Chemical Property:

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Technology Process of 2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

There total 1 articles about 2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 1055962-39-4
2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / 10 h / 165 °C / Heating / reflux

2: trichlorophosphate / 12 h / Heating / reflux

With ammonium acetate; trichlorophosphate;

Reference yield:

: 1055962-39-4
2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

: 1055969-37-3
{3-[5-(4-amino-8,9-dimethoxy-benzo[c][2,7]naphthyridin-2-yl)-pyridin-3-yl]-1-benzyl-prop-2-ynyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran; water / 6 h

1.2: 10 h / 2585.81 Torr

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / -60 - 15 °C

2.2: 1 h

3.1: ammonium acetate / phenol / 2 h / 100 °C

4.1: piperidine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1 h / Heating / reflux

With piperidine; ammonium acetate; potassium carbonate; lithium hexamethyldisilazane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; water; phenol;

Reference yield:

: 1055962-39-4
2-chloro-6,7-dimethoxy-4-methyl-quinoline-3-carbonitrile hydrochloride

: 1055964-32-3
2-(5-{3-[benzyl(methyl)amino]prop-1-yn-1-yl}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran; water / 6 h

1.2: 10 h / 2585.81 Torr

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / -60 - 15 °C

2.2: 1 h

3.1: ammonium acetate / phenol / 2 h / 100 °C

4.1: piperidine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 0.75 h / Heating / reflux

With piperidine; ammonium acetate; potassium carbonate; lithium hexamethyldisilazane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; water; phenol;