tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

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Chemical Name:tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
CAS No.:1539320-48-3
Molecular Formula:C₃₄H₄₆BrN₅O₆
Molecular Weight:700.673
Hs Code.:

tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Synonyms:tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

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Chemical Property of tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

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Technology Process of tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

There total 8 articles about tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1539320-81-4
(S)-2-((S)-1-(2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)benzoyl)pyrrolidine-2-carboxamido)-4-methyl pentanoic acid

: 106-40-1
4-bromo-aniline

: 1539320-48-3
tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/c3ob42016g

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1539320-48-3
tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h

6: lithium hydroxide dihydrate / tetrahydrofuran; water

7: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

With dmap; lithium hydroxide dihydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob42016g

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 1539320-48-3
tert-butyl ((R)-1-((2-((S)-2-(((S)-1-((4-bromophenyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-phenyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h

6: lithium hydroxide dihydrate / tetrahydrofuran; water

7: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

With dmap; lithium hydroxide dihydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c3ob42016g