3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

Base Information

Chemical Name:3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide
CAS No.:1316808-25-9
Molecular Formula:C₂₃H₃₁N₃O₃S
Molecular Weight:429.583
Hs Code.:

Synonyms:3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

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Technology Process of 3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

There total 6 articles about 3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1316808-00-0
3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-amine

: 108-12-3
isopentanoyl chloride

: 1316808-25-9
3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

Guidance literature:: With polystyrene N-methylmorpholine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2011.05.025

Reference yield:

: 883738-19-0
1,1-dimethylethyl 4-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-1-piperazinecarboxylate

: 1316808-25-9
3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 0.17 h / 150 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 20 °C

3: polystyrene N-methylmorpholine / dichloromethane / 16 h / 20 °C

4: hydrogen / ethanol; ethyl acetate / 65 °C

5: polystyrene N-methylmorpholine / dichloromethane / 1 h / 20 °C

With tetrabutylammomium bromide; hydrogen; palladium diacetate; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; water; ethyl acetate; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2011.05.025

Reference yield:

: 1316807-33-6
tert-butyl 4-((4'-nitrobiphenyl-3-yl)methyl)piperazine-1-carboxylate

: 1316808-25-9
3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: polystyrene N-methylmorpholine / dichloromethane / 16 h / 20 °C

3: hydrogen / ethanol; ethyl acetate / 65 °C

4: polystyrene N-methylmorpholine / dichloromethane / 1 h / 20 °C

With hydrogen; trifluoroacetic acid; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2011.05.025