(3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

Base Information

Chemical Name:(3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one
CAS No.:439143-38-1
Molecular Formula:C₂₁H₃₃NO₄SSi
Molecular Weight:423.649
Hs Code.:

Synonyms:(3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

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Chemical Property of (3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

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Technology Process of (3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

There total 2 articles about (3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 439143-62-1
(5S,1R,2R,5R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthiobicyclo[4.3.0]nonan-8-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: (5S,1R,2R,3R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

: 439143-38-1
(3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 6h;
DOI:10.1016/j.tet.2008.02.001

Reference yield:

: Acetic acid (3R,4R,6S)-5-benzyloxycarbonylamino-4-hydroxy-3-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: (5S,1R,2R,3R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

: 439143-38-1
(3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

Guidance literature:: Acetic acid (3R,4R,6S)-5-benzyloxycarbonylamino-4-hydroxy-3-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yl ester; With boron trifluoride diethyl etherate; thiophenol;

With sodium hydride;

t-butyldimethylsiyl triflate; Further stages.;
DOI:10.1021/ja026235n

Reference yield:

: 439143-38-1
(3S,5S,1R,2R,6R)-7-aza-2-methoxy-1,5-dimethyl-4,9-dioxa-3-phenylthio-7-(1,1,2,2-tetramethyl-1-silapropyl)bicyclo[4.3.0]nonan-8-one

: 439143-48-3
(1S,5R,9R,10R,11R,12R,13S)-13-hydroxy-1,9-dimethoxy-5-[(4-methoxyphenyl)methoxymethyl]-7,10,12-trimethyl-4,15-dioxabicyclo[9.3.1]pentadec-7-en-3-one

: 439143-64-3
3-(tert-butyl-dimethyl-silanyl)-6-[1,9-dimethoxy-5-(4-methoxy-benzyloxymethyl)-7,10,12-trimethyl-3-oxo-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-13-yloxy]-7-methoxy-4,7a-dimethyl-tetrahydro-pyrano[3,4-d]oxazol-2-one

Guidance literature:: With N-iodo-succinimide; 2,6-di-tert-butyl-4-methylpyridine; trifluorormethanesulfonic acid; In dichloromethane; at -15 - 20 ℃;
DOI:10.1021/ja026235n