(1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid

Base Information

• Chemical Name: (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid
• CAS No.: 51111-13-8
• Molecular Formula: C₁₁H₁₈O₄
• Molecular Weight: 214.262
• Mol file: 51111-13-8.mol

Synonyms:(1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid

Chemical Property of (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid

There total 9 articles about (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4-dimethylcyclohexane-1-one (4255-62-3) → (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid (51111-13-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate, acetic acid / toluene / Heating

2: ethanol; H₂O / 5 h / Heating

3: acetic acid, HCl, H₂O / 84 h / Heating

With ammonium acetate; hydrogenchloride; water; acetic acid; In ethanol; water; toluene;

DOI:10.1021/jm00173a010

Reference yield:

cyano-(4,4-dimethyl-cyclohexyliden)-acetic acid ethyl ester (39858-62-3) → (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid (51111-13-8)

Guidance literature:

With potassium cyanide; ethanol; Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;

DOI:10.1021/ja01296a031

Reference yield:

3,3-dimethylpent-1,5-diol (53120-74-4) → (1-carboxy-4,4-dimethyl-cyclohexyl)-acetic acid (51111-13-8)

Guidance literature:

Multi-step reaction with 6 steps

1: SOCl₂

3: concentrated H₂SO₄

4: aqueous Ba(OH)2-solution

5: piperidine

6: ethanol; aqueous potassium cyanide / Erwaermen des Reaktionsprodukts mit wss. Salzsaeure

With piperidine; potassium cyanide; barium dihydroxide; thionyl chloride; ethanol; sulfuric acid;

DOI:10.1021/ja01296a031

upstream raw materials:

cyano-(4,4-dimethyl-cyclohexyliden)-acetic acid ethyl ester

potassium cyanide

4,4-dimethylcyclohexane-1-one

3,3-dimethylpent-1,5-diol

Downstream raw materials:

8,8-dimethyl-2-oxa-spiro[4.5]decane-1,3-dione