benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

Base Information

Chemical Name:benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate
CAS No.:1413936-78-3
Molecular Formula:C₃₂H₄₅N₅O₇S
Molecular Weight:643.805
Hs Code.:

benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

Synonyms:benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

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Chemical Property of benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

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Technology Process of benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

There total 5 articles about benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1413936-77-2
benzyl 4-(2-((R)-(9H-9-fluorenylmethoxycarboxamido))-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

: 1413936-78-3
benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: With piperidine; In acetonitrile; at 20 ℃; for 3h;
DOI:10.3762/bjoc.8.142

Reference yield:

: 557087-61-3
benzyl 4-aminotetrahydro-2H-pyran-4-carboxylate

: 1413936-78-3
benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

2: piperidine / acetonitrile / 3 h / 20 °C

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;
DOI:10.3762/bjoc.8.142

Reference yield:

: 172843-97-9
4-(Boc-amino)tetrahydropyran-4-carboxylic acid

: 1413936-78-3
benzyl 4-(2-((R)-amino)-5-(3-[(2,3-dihydro-2,2,4,6,7-pentamethyl-2H-1-benzofuran-5-yl)sulfonyl]guanidino)pentanamido)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h / 20 °C

4: piperidine / acetonitrile / 3 h / 20 °C

With piperidine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; acetone; acetonitrile;
DOI:10.3762/bjoc.8.142