2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

• Chemical Name: 2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
• CAS No.: 173169-13-6
• Molecular Formula: C₂₉H₄₅N₃O₁₁SSi₂
• Molecular Weight: 699.927

Synonyms:2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Chemical Property of 2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Technology Process of 2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 2 articles about 2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(4-nitro-phenyl)ethanesulfonyl chloride (80259-15-0) + 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (173169-13-6)

Guidance literature:

With pyridine; for 1h; Ambient temperature;

DOI:10.1002/hlca.19950780706

Reference yield:

2-(4-nitrophenyl)ethyl chloride (20264-95-3) → 2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (173169-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Na₂S₂O₃*5H₂O, 2.) ice, AcOH, Cl₂ gas / 1.) MeOH/water, 7-8 h, reflux, 2.) MeOH, water, 30 min

2: 75 percent / pyridine / 1 h / Ambient temperature

With pyridine; Methamphetamin; chlorine; sodium thiosulfate; acetic acid;

DOI:10.1002/hlca.19950780706

Reference yield: 69.0%

2'-O-<2-(4-nitrophenyl)ethylsulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (173169-13-6) → 3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine (173169-22-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.75h; Ambient temperature;

DOI:10.1002/hlca.19950780706

upstream raw materials:

2-(4-nitro-phenyl)ethanesulfonyl chloride

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

2-(4-nitrophenyl)ethyl chloride

Downstream raw materials:

3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

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