7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

Base Information

Chemical Name:7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid
CAS No.:1616278-01-3
Molecular Formula:C₂₅H₂₅F₂N₅O₅S
Molecular Weight:545.567
Hs Code.:

7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

Synonyms:7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

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Chemical Property of 7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

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Technology Process of 7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

There total 1 articles about 7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874-61-3
4-oxocyclohexanecarboxylic acid

: 1657034-44-0
tert-butyl (3-(benzyloxy)-5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-2-(ethylcarbamoyl)-4-oxopyridin-1(4H)-yl)(methyl)carbamate

: 1616278-01-3
7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

Guidance literature:: With dichloro-acetic acid; at 100 ℃; for 4h;

Reference yield:

: 288315-03-7
3,3-difluoroazetidine hydrochloride

: 1616278-01-3
7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

: 1616276-50-6
7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

: 1616276-48-2
7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid

Guidance literature:: 3,3-difluoroazetidine hydrochloride; 7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With potassium carbonate; In methanol; water; N,N-dimethyl-formamide; at 20 ℃; for 16h;