288315-03-7

Basic information

• Product Name: 3,3-DIFLUOROAZETIDINE HYDROCHLORIDE
• Synonyms: 3,3-DIFLUOROAZETIDINE HYDROCHLORIDE;3,3-DIFLUOROAZETIDINE HCL;3,3-Difluoroazetidine hyd...;3,3-difluoroazetidine;Azetidine, 3,3-difluoro-, hydrochloride (1:1);3,3-Difluoroaztidine hydrochloride;3,3-Difluoroazetidine hydrochloride 97%
• CAS NO: 288315-03-7
• Molecular Formula: C₃H₅F₂N*ClH
• Molecular Weight: 129.54
• Product Categories: Pyridines ,Heterocyclic Acids
• Mol File: 288315-03-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138-143 °C
• Boiling Point: 51.5 °C at 760 mmHg
• Appearance: white or light brown crystalline powder
• Vapor Pressure: 275mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Water (Slightly)
• Sensitive: Hygroscopic
• CAS DataBase Reference: 3,3-DIFLUOROAZETIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIFLUOROAZETIDINE HYDROCHLORIDE(288315-03-7)
• EPA Substance Registry System: 3,3-DIFLUOROAZETIDINE HYDROCHLORIDE(288315-03-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 288315-03-7(Hazardous Substances Data)

Usage

Uses

3,3-Difluoroazetidine Hydrochloride is used in preparation of Dihydropyrimidine compounds as antiviral agents.

InChI:InChI=1/C3H5F2N.ClH/c4-3(5)1-6-2-3;/h6H,1-2H2;1H

Upstream product

• 288315-02-6 3,3-difluoro-1-benzhydrylazetidine 

Downstream Products

• 1022931-78-7 3,3-difluoro-1-[(4-iodophenyl)carbonyl]azetidine 
• 960003-55-8 (3,3-difluoro-azetidin-1-yl)-(9-methoxy-2,3-dimethyl-9-(2-methylphenyl)-7H-8,9-dihydro-pyrano[2,3-c]-imidazo[1,2-a]pyridin-6-yl)-methanone 
• 2592-95-2 benzotriazol-1-ol 
• 632-22-4 tetramethylurea 
• 1443432-73-2 benzyl (3,3-difluoroazetidin-1-yl)sulfonylcarbamate 
• 1621255-62-6 C₃₈H₃₂F₁₂N₂O₃ 
• 1616276-50-6 7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid 
• 1616276-48-2 7'-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3'-ethyl-5'-hydroxy-1'-methyl-4',6'-dioxo-1',3',4',6'-tetrahydrospiro[cyclohexane-1,2'-pyrido[2,1-f][1,2,4]triazine]-4-carboxylic acid 
• 1446236-43-6 1-((3-bromo-4-fluorophenyl)sulfonyl)-3,3-difluoroazetidine 
• 1578244-20-8 8-(3,3-difluoroazetidin-1-yl)-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine 
• 1578484-72-6 (4-amino-3-methoxyphenyl)(3,3-difluoroazetidin-1-yl)methanone 
• 1544740-23-9 3-(4-bromo-3,5-dimethylphenoxy)-1-(3,3-difluoroazetidin-1-yl)propan-1-one 

Relevant articles and documents

Energetic materials with fluorinated four-membered heterocyclic ring: 3,3′-difluoroazetidine (DFAZ) salts

3,3′-Difluoroazetidinium (DFAZ) possesses a high-tensile four-membered ring and fluorine atoms, which contributes to the specific impulse, detonation pressure and detonation velocity. High-density energetic salts that contain oxygen-rich anions and cations were synthesized. All of the salts were fully characterized by IR spectroscopy, single-crystal X-ray diffraction, elemental analysis, differential scanning calorimetry (DSC) as well as impact and friction sensitivity. Their detonation properties were calculated according to the densities and heats of formation. The results showed that compared to ADN, they all had a relatively high density and low impact sensitivity. The specific impulse of almost all of the salts were higher than that of the propellant component, ammonium dinitramide (ADN, Isp = 202 J). Moreover, the 3,3′-difluoroazetidinium nitroformate salt had the highest specific impulse and was relatively more stable. It is possible to obtain energetic cations with good properties by combining four-membered high-tension rings with fluorine atoms.

TAXANE COMPOUND WITH AZETIDINE RING STRUCTURE

A compound represented by the general formula (1) [X1 and X2 represent hydrogen atom, a halogen atom, hydroxyl group and the like, R1 represents a phenyl group, R2 represents an alkyl group, an alkenyl group, or