(Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester

Base Information

• Chemical Name: (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester
• CAS No.: 443147-09-9
• Molecular Formula: C₃₇H₆₄O₆Si₂
• Molecular Weight: 661.083

Synonyms:(Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester

Chemical Property of (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester

There total 14 articles about (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(Z)-7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester (443147-08-8) → (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester (443147-09-9)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -70 ℃; for 1h;

DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester (443147-09-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 97 percent / imidazole / dimethylformamide / 20 °C

2.1: Cp₂ZrClH / tetrahydrofuran / 0.75 h / 20 °C

2.2: 80 percent / I₂ / tetrahydrofuran / 0.25 h / 0 °C

3.1: t-BuLi / diethyl ether; pentane / 1 h / -70 °C

3.2: 90 percent / lithium 2-thienylcyanocuprate / diethyl ether; pentane; tetrahydrofuran / -70 - -20 °C

4.1: 42 percent / lithium tris-s-butylborohydride / tetrahydrofuran / 1 h / -70 °C

With 1H-imidazole; Schwartz's reagent; tert.-butyl lithium; L-Selectride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;

DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

(3S)-4-(3-methoxymethylphenyl)-1-butyn-3-ol (253350-38-8) → (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester (443147-09-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 97 percent / imidazole / dimethylformamide / 20 °C

2.1: Cp₂ZrClH / tetrahydrofuran / 0.75 h / 20 °C

2.2: 80 percent / I₂ / tetrahydrofuran / 0.25 h / 0 °C

3.1: t-BuLi / diethyl ether; pentane / 1 h / -70 °C

3.2: 90 percent / lithium 2-thienylcyanocuprate / diethyl ether; pentane; tetrahydrofuran / -70 - -20 °C

4.1: 42 percent / lithium tris-s-butylborohydride / tetrahydrofuran / 1 h / -70 °C

With 1H-imidazole; Schwartz's reagent; tert.-butyl lithium; L-Selectride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;

DOI:10.1016/S0968-0896(02)00031-7

upstream raw materials:

(Z)-7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-hept-5-enoic acid methyl ester

3-(methoxymethyl)bromobenzene

tert-butyldimethylsilyl chloride

(3S)-4-(3-methoxymethylphenyl)-1-butyn-3-ol

Downstream raw materials:

(Z)-7-{(1R,2R,3R,5R)-5-Fluoro-3-hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-cyclopentyl}-hept-5-enoic acid methyl ester

(Z)-7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-cyclopentyl}-hept-5-enoic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 443147-09-9 (Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send