N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide

Base Information

• Chemical Name: N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide
• CAS No.: 191993-62-1
• Molecular Formula: C₁₄H₁₅ClN₂O₃S
• Molecular Weight: 326.804
• Mol file: 191993-62-1.mol

Synonyms:N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide

Chemical Property of N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide

There total 1 articles about N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3-isopropoxyaniline (41406-00-2) + 4-chloro-pyridine-3-sulfonyl chloride (33263-44-4) → N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide (191993-62-1)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 1h; sulfonyl chloride adding dropwise to aniline and Et₃N; stirring; evapg.; dissolving in aq. NaOH; ppt. treating with 1 M HCl;

Reference yield: 85.0%

N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide (191993-62-1) → N-(3-isopropoxyphenyl)-4-aminopyridine-3-sulphonamide (191993-63-2)

Guidance literature:

With ammonia; In ammonium hydroxide; at 150 ℃; for 12h; Heating; heating in autoclave; concg,; ppt. collecting; washing with water; drying;

Reference yield:

N-(3-isopropoxyphenyl)-4-chloropyridine-3-sulphonamide (191993-62-1) → 3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (191993-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NH₃ / aq. NH₃ / 12 h / 150 °C / Heating; heating in autoclave; concg,; ppt. collecting; washing with water; drying

2: 54 percent / dimethylformamide / 1.5 h / Heating; heating under reflux; evapg.; dissolving in water; pH adjusting to 12 with aq. NaOH; ppt. collecting, washing with water

With ammonia; In ammonium hydroxide; N,N-dimethyl-formamide; 1: Substitution / 2: Cyclization;

upstream raw materials:

3-isopropoxyaniline

4-chloro-pyridine-3-sulfonyl chloride

Downstream raw materials:

N-(3-isopropoxyphenyl)-4-aminopyridine-3-sulphonamide

3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide