3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Base Information

Chemical Name:3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
CAS No.:191993-65-4
Molecular Formula:C₁₈H₁₇N₅O₃S
Molecular Weight:383.431
Hs Code.:

Synonyms:

Suppliers and Price of 3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

There total 4 articles about 3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 191993-63-2
N-(3-isopropoxyphenyl)-4-aminopyridine-3-sulphonamide

: 191993-65-4
3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Guidance literature:: In N,N-dimethyl-formamide; for 1.5h; Heating; heating under reflux; evapg.; dissolving in water; pH adjusting to 12 with aq. NaOH; ppt. collecting, washing with water;

Reference yield:

: 41406-00-2
3-isopropoxyaniline

: 191993-65-4
3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / triethylamine / dioxane / 1 h / 20 °C / sulfonyl chloride adding dropwise to aniline and Et₃N; stirring; evapg.; dissolving in aq. NaOH; ppt. treating with 1 M HCl

2: 85 percent / NH₃ / aq. NH₃ / 12 h / 150 °C / Heating; heating in autoclave; concg,; ppt. collecting; washing with water; drying

3: 54 percent / dimethylformamide / 1.5 h / Heating; heating under reflux; evapg.; dissolving in water; pH adjusting to 12 with aq. NaOH; ppt. collecting, washing with water

With ammonia; triethylamine; In 1,4-dioxane; ammonium hydroxide; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Cyclization;

Reference yield:

: 33263-44-4
4-chloro-pyridine-3-sulfonyl chloride

: 191993-65-4
3-(1H-imidazol-1-yl)-2-(3-isopropoxyphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / triethylamine / dioxane / 1 h / 20 °C / sulfonyl chloride adding dropwise to aniline and Et₃N; stirring; evapg.; dissolving in aq. NaOH; ppt. treating with 1 M HCl

2: 85 percent / NH₃ / aq. NH₃ / 12 h / 150 °C / Heating; heating in autoclave; concg,; ppt. collecting; washing with water; drying

3: 54 percent / dimethylformamide / 1.5 h / Heating; heating under reflux; evapg.; dissolving in water; pH adjusting to 12 with aq. NaOH; ppt. collecting, washing with water

With ammonia; triethylamine; In 1,4-dioxane; ammonium hydroxide; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Cyclization;