(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

Base Information

Chemical Name:(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate
CAS No.:1367878-69-0
Molecular Formula:C₂₁H₂₉F₂NO₇
Molecular Weight:445.461
Hs Code.:

Synonyms:(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

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Chemical Property of (2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

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Technology Process of (2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

There total 5 articles about (2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1367878-66-7
(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

: 1367878-69-0
(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

Guidance literature:: With 20% palladium hydroxide on charcoal; hydrogen; In tetrahydrofuran; for 18h; under 760.051 Torr;
DOI:10.1016/j.jfluchem.2012.01.003

Reference yield:

: 1367878-65-6
(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

: 1367878-69-0
(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride; dihydrogen peroxide; sodium hydrogencarbonate / tetrahydrofuran; methanol; water / 18 h / 23 °C / Inert atmosphere

2: 20% palladium hydroxide on charcoal; hydrogen / tetrahydrofuran / 18 h / 760.05 Torr

With potassium fluoride; 20% palladium hydroxide on charcoal; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.jfluchem.2012.01.003

Reference yield:

: 704910-38-3
(3S,3aS,7aR)-3-Formyl-2-(4-methoxy-benzyl)-3a,5,5-trimethyl-1-oxo-octahydro-4-oxa-2-aza-5-sila-indene-3-carboxylic acid methyl ester

: 1367878-69-0
(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybutyl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran; diethyl ether; pentane / 1.5 h / Inert atmosphere; Cooling

2: potassium fluoride; dihydrogen peroxide; sodium hydrogencarbonate / tetrahydrofuran; methanol; water / 18 h / 23 °C / Inert atmosphere

3: 20% palladium hydroxide on charcoal; hydrogen / tetrahydrofuran / 18 h / 760.05 Torr

With potassium fluoride; n-butyllithium; 20% palladium hydroxide on charcoal; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; diethyl ether; water; pentane;
DOI:10.1016/j.jfluchem.2012.01.003